Metal- and acid-free, TBN-mediated direct C-H nitration of arenes
| 发表年度： |
2019 |
| 期： |
7 |
| 卷： |
23 |
| 页： |
896-902 |
| 摘要： |
A metal-free, acid-free, direct and eco-friendly nitration methodology has been developed. A tert-butyl nitrite efficiently promotes the direct C-H nitration of electron-rich arenes with good to excellent yields and regioselectivities. The practical utility of this protocol has been demonstrated in gram-scale nitration of crown ether and mono nitration of Sesamin. A plausible free radical mechanism is proposed based on detailed experimental observations. (C) 2019 Production and hosting by Elsevier B.V. on behalf of King Saud University. |
| 刊物名称： |
JOURNAL OF SAUDI CHEMICAL SOCIETY |
| 影响因子： |
2.759 |
