Synthesis and application of alpha-carbonyl nitrile oxides
| 发表年度： |
2020 |
| 期： |
17 |
| 卷： |
7 |
| 页： |
2467-2473 |
| 摘要： |
A novel strategy for synthesizing alpha-carbonyl nitrile oxides has been developed utilizingtert-butyl nitrite (TBN) as a nitrogen source. A diverse range of alpha-carbonyl furoxans and alpha-carbonyl isoxazoles have been obtained in good to excellent yields, including aromatic and aliphatic products. The practical utility of this protocol has been demonstrated in gram-scale experiments and the syntheses of some bioactive molecules. A plausible free radical mechanism involving alpha-nitro ketone intermediates is proposed based on mechanistic investigations. |
| 刊物名称： |
ORGANIC CHEMISTRY FRONTIERS |
| 影响因子： |
5.076 |
