A pincer ligand enabled ruthenium catalyzed highly selective N-monomethylation of nitroarenes with methanol as the C1 source
| 发表年度： |
2019 |
| 期： |
15 |
| 卷： |
6 |
| 页： |
2726-2731 |
| 摘要： |
A straightforward and highly selective N-monomethylation of nitro compounds with methanol as the C1 source was developed by employing [RuCl2(p-cymene)(2)](2) as the catalyst and an NNN pincer (amine-pyridine-imine, API) as the ligand. This protocol was found to be highly selective and effective in the N-monomethylation of a broad spectrum of nitroarenes including pharmaceutically relevant nitro compounds with good tolerance of a set of functional groups. The mechanistic studies revealed that the reaction proceeded via a borrowing-hydrogen pathway in a one-pot cascade manner and methanol serves as both a hydrogen source and a methylation agent. |
| 刊物名称： |
ORGANIC CHEMISTRY FRONTIERS |
| 影响因子： |
5.076 |
