| 第一作者： | Nair, S (Nair, Sachin); Gao, J (Gao, Jun); Otto, C (Otto, Cees); Duits, MHG (Duits, Michael H. G.); Mugele, F (Mugele, Frieder); |
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| 联系作者： | Nair, S (Nair, Sachin); Gao, J (Gao, Jun); Otto, C (Otto, Cees); Duits, MHG (Duits, Michael H. G.); Mugele, F (Mugele, Frieder); |
| 发表年度： | 2021 |
| 期： | 38 |
| 卷： | 93 |
| 页： | 12966-12972 |
| 摘要： | We demonstrate how algorithm-improved confocal Raman microscopy (ai-CRM), in combination with chemical enhancement by two-dimensional substrates, can be used as an ultrasensitive detection method for rhodamine (R6G) molecules adsorbed from aqueous solutions. After developing a protocol for laser-induced reduction of graphene oxide, followed by noninvasive Raman imaging, a limit of detection (LOD) of 5 x 10(-10) M R6G was achieved using ai-CRM. An equivalent subnanomolar LOD was also achieved on another graphene oxide analogue -UV/ozone-oxidized graphene. These record-breaking detection capabilities also enabled us to study the adsorption kinetics and image the spatial distribution of the adsorbed R6G. These findings indicate a strong potential for algorithm-improved graphene-enhanced Raman spectroscopy as a facile method for detecting, imaging, and quantifying trace amounts of adsorbing molecules on a variety of 2D substrates. |
| 刊物名称： | ANALYTICAL CHEMISTRY |
| 影响因子： | 6.35 |
| 全文链接： | https://pubs.acs.org/doi/10.1021/acs.analchem.1c02581 |
